Conductometric determination of Betahistine dihydrochloride and Heptaminol hydrochloride using silver nitrate

Document Type : Original Article

Authors

1 Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig,Egypt

2 Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, Egypt

3 Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt

Abstract

A simple, precise and cost effective conductometric method was developed for determination of betahistine dihydrochloride and heptaminol hydrochloride in pure form and pharmaceutical formulations. The method is based on the precipitation of chloride ions present in cited drugs with silver ions, yielding silver chloride, the conductance of the solution is measured as a function of the volume of titrant. Effect of solvent, reagent concentration, temperature were studied and evaluated. The suggested method was applied for determination of betahistine dihydrochloride and heptaminol hydrochloride in pure forms and pharmaceutical preparations. The described procedure allowed the determination of betahistine dihydrochloride and heptaminol hydrochloride in the range of 2-10mg/ml and 2-13mg /ml respectively.The molar ratio was (2:1),(1:1) (drug:reagent) between betahistine dihydrochloride and heptaminol hydrochloride with silver nitrate respectively. The suggested procedure was applied successfully to the analysis of these drugs in their pharmaceutical formulations, and the results obtained were in agreement with those given by the official methods

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