Repurposing Finasteride as a quorum sensing inhibitor in Pseudomonas aeruginosa

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Document Type : Original Article

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Zagazig University

Abstract

The emergence of antimicrobial resistance is considered a great problem on a global scale. The decreased supply of antibiotics newly developed adds to this problem needing alternatives such as inhibition of quorum sensing-regulated virulence. Pseudomonas aeruginosa is an opportunistic micror causing nosocomial infections in severely ill and immunocompromised patients. Ubiquitously disseminated in the environment, especially in hospitals, it has become a major threat to human health due to the constant emergence of drug-resistant strains. Quorum sensing inhibitors can attenuate the pathogenesis of bacteria and help the immune system to eradicate them without targeting the bacterial growth.
Finasteride was repurposed to test its potential anti-virulence activity against Pseudomonas aeruginosa including biofilm, pyocyanin, protease and swarming motility. Finasteride could siginificntly decreased biofilm formation by 45% , pyocyanin production was diminished to 49% protease and swarming were decreased by 42% and 39% accordingly.
In conclusion, finasteride could be employed in treating Pseudomonas aeruginosa infections.

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Zagazig Journal of Pharmaceutical Sciences

Articles in Press, Accepted Manuscript
Available Online from 13 May 2025

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