Evaluation of Conventional Karyotyping, Lactate Dehydrogenase Levels, White Blood Cells count, and Bone Marrow Blast Percentage as Good Prognostic Tests in Patients Diagnosed with Acute Myeloid Leukemia

Document Type : Original Article

Authors

1 Dept. of Biotechnology Engineering, Faculty of Technology, Aleppo University

2 Dept. of Biochemistry and Clinical, Faculty of Pharmacy, Ebla Private University

3 Dept. of Hematology, Faculty of Medicine, Aleppo University

Abstract

Acute myeloid leukemia (AML) is a kind of hematologic malignancy in which overall survival (OS) may be affected by many factors such as the patient's age, gender, conventional karyotyping (CK) findings, lactate dehydrogenase (LDH) concentration, white blood cells (WBC) count, and bone marrow blast (BMB) percentage at diagnosis. In this study, we aimed to evaluate the prognostic significance of those characteristics on OS at diagnosis. The current study included 98 AML patients who have been examined for cytology, CK, and immunophenotyping. The average patient’s age was 39 years old. In addition, around 56% of patients had a chromosomal abnormality. Furthermore, the patients with LDH levels higher than 450 IU/L, WBC counts over 50 X109/L, BMB% more than 50%, and AML-M0 had a shorter OS compared to other groups. However, the results suggested that CK, LDH, WBC count, and BMB% might be used as good prognostic tests in patients with AML at diagnosis.

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