SYNTHESIS OF NEW CONDENSED PYRIMIDINES: I

Document Type : Original Article

Authors

1 Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt

2 Pharmaceutical Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt

3 Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.

4 Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt

5 Pharmaceutical Chemistry Department, Faculty of Pharmacy, university of Cairo, Egypt .

Abstract

2-Dicyanomethylidinoindoline (I) obtained from lactime ether of  oxindole and malononitrile, when added to various isocyanates or isothiocyanates afforded 2-alkye-3-imino-1-oxo or thioxo-1,2,3,4,4a,5-hexahydro-pyrimido1,6-alindole-4-carbonitrile. The corresponding enaminonitriles were obtained by reduction with sodium borohydride. Álkylation and hydrolysis of the prepared compounds are also described .

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