PRAZIQUANTEL- INDUCED TRANSIENT HYPOTENSION, DEPRESSED RESPIRATION AND ALTERED ELECTOCARDIOGRAM (ECG).

Document Type : Original Article

Authors

1 Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, Egypt.

2 Department of Pharmacology, Faculty of Vet. Medicine, Zagazig University

3 Pharmacology Department, Faculty of Vet. Med., Zagazig University, Egypt

Abstract

A relaxant effect was achieved by praziquantel on the rat thoracic aortic strip preparations which might be of cholinergic nature.
Praziquantel produced an acetylcholine-like effect on the perfused rabbit's heart.
A transient hypotensive effect and respiratory depression and altered ECG were traced. These effects revealed the peripheral cholinergic effects of the drug.

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