SYNTHESIS OF NEW CONDENSED PYRIMIDINES : III

Ebeid, Mohamed; Lashine, Sayed; Abou Taleb, Nageh; Abdel-Aziz, Lobna

doi:10.21608/zjps.1993.189002

SYNTHESIS OF NEW CONDENSED PYRIMIDINES : III

Document Type : Original Article

Authors

¹ Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt

² Pharmaceutical Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt

³ FACULTY OF PHARMACY, CAIRO UNIVERSITY

⁴ Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt

10.21608/zjps.1993.189002

Abstract

Acylation of the o-aminonitrile (enaminonitrile) derivatives of certain pyrimido- [1, 6-a] indole, with acid anhydrides or acid chlorides was achieved yielding a tetracylic structure, pyrimido- [4',5' : 4,5 ] pyrimido [1,6-a] indole. The chlorine atom in the chloroalkyl moiety was replaced by different amines or condensed with thiourea and the formed salts were hydrolyzed to give the mercapto alkyl compounds. Moreover, enaminonitriles were reacted with oxalyl chloride to afford the 3-chlorocarbonyl derivatives from which esters and amides were prepared. The 3-carboxylic acid derivtives were also prepared and subjected to decarboxylation. Some of the prepared compounds were tested for their pharmacological activties.