SYNTHESIS AND PRELIMINARY TESTING OF SOME ANTHRANILIC ACID DERIVATIVES AS ANTIINFLAMMATORY, ANALGESIC AND ANTIPYRETIC AGENTS

Document Type : Original Article

Authors

1 Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt

2 Pharmaceutical Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt

3 Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.

4 FACULTY OF PHARMACY, CAIRO UNIVERSITY

5 Department of Pharmacology, Faculty of Veterinary Medicine, University of Mansoura, Egypt.

Abstract

A series of N - 3 - chloro -N- substituted phenyl -2- maleimidyl  anthranilic acid and its methyl ester were prepared. The reaction of either IV or V with potassium thiocyanate afforded quinazolinone thione derivatives. four of the prepared new compounds were screened pharmacologically for their antiinflammatory, analgesic and antipyretic properties.

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