SYNTHESIS OF SOME 1,3,4- OXADIAZOLES FROM ETHYL IMIDAZO [4,5-B] PYRIDINYL PROPIONATE AS PONTENTIAL ANTIINFLAMMATORY AGENTS

Document Type : Original Article

Authors

1 Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt

2 Pharmaceutical Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt

3 FACULTY OF PHARMACY, CAIRO UNIVERSITY

4 Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt

5 Department of Pharmacology, Faculty of Veterinary Medicine, University of Mansoura, Egypt.

Abstract

Synthesis of 2- (6-bromo -2- imidazo  [4,5-b] pyridinyl) ethyl -5-( substituted) thío 1,3,4 Oxadiazole derivatives is described. The preparation of 1,3,4 - Oxadiazoles was achieved by cyclization of the corresponding acid hydrazide. Mannich reaction was applied on these new oxadiazoles giving the corresponding Mannich bases .Two of the prepared compounds were tested for their analgesic, antipyritic and antiinflammatory activities to show promising effects.

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