SYNTHESIS OF CERTAIN SUBSTITUTED 7-CHLORO-4- QUINAZOLONES OF PHARMACEUTICAL INTEREST

Document Type : Original Article

Authors

1 Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

2 Department of Organic Chemistry, Faculty of Pharmacy, Cairo University

Abstract

The synthesis of some N-(7-chioro-3-phenyl-4 (3H)-quinazolinon-2-ylmercaptoacetyi) hydrazones is described. Reacting 7-chloro-3-phenyl-4-quinazolinone-2-thione with ethyl chloroacetate yielded two isomeric esters. Condensation of these esters with hydrazine hydrate under different reaction conditions afforded the expected hydrazides in addition to some sulphur free products.