SPECTRODENSITOMETRIC DETERMINATION OF CERTAIN DIUTRETIC MIXTURES

Document Type : Original Article

Authors

1 Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt

2 Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.

3 Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt

Abstract

A simple and direct spectrodensitometric method has been developed for the qualitative and quantitative determination of three pairs of diuretic mixtures: i- spironolactone with hydrochlorothiazide, ii- captopril with hydrochlorothiazide and ii- spironolactone with furosemide p-Chloroacetanilide was used as internal standard in quantitative determination. The method was applied for the determination of these drugs in different pharmaceutical dosage forms: Aldactazide, Capozide tablets and Fructone capsules. The results indicated high accuracy and reproducibility.

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