PHARMACOLOGICAL EVALUATION OF TOLTRAZURIL WITH SPECIAL REFERENCE TO ITS ADVERSE EFFECTS

Abd El Aziz, Mostafa; Abdel-Motal, Sabri; Khairy, Mohamed; El-Gammal, Ashour; Shams, Gamal; Fouad, Abdel-Alem; Mankarios, Elene

doi:10.21608/zjps.1993.187359

PHARMACOLOGICAL EVALUATION OF TOLTRAZURIL WITH SPECIAL REFERENCE TO ITS ADVERSE EFFECTS

Document Type : Original Article

Authors

¹ Department. of pharmacology, Faculty of Veterinary Medicine, Zagazig University.

² Pharmacology Department, Faculty of Vet. Med., Zagazig University, Egypt.

³ Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, Egypt.

⁴ Pharmacology Department, Faculty of Vet. Med., Zagazig University, Egypt

10.21608/zjps.1993.187359

Abstract

Toltrazuril which is a novel anticoccidial agent elicit an inhibitory effect on the isolated smooth muscles of both intestine and oviduct of chicken. It was proved that its effect is due to an antihistamine-like effect. Toltrazuril exerted a negative inotropic effect on isolated chicken's heart with a decrease in coronary outflow. The drug induced hypotension with increased respiratory rate. Moreover, oral adminstration of toltrazuril produced a significant increase in serum GOT, glucose, creatinine and uric acid. The drug elicited a significant decrease in serum GPT, total protein and cholesterol levels. Histopathological findings were discussed.