Serotonin (5-HT) 1A receptors have been shown to have physiological, biochemical pharmacological and clinical values. The piperazino derivative 1 was rationally designed as a bulky, lipophilic N4-substituted arylpiperazine. Radioligand binding assay of 1 at 5-HT1A receptors indicates that it binds at these receptors with higher affinity than the famous 5-HT1A, ligand, buspirone (Ki = 15 nM). Buspirone is currently used to treat anxiety.
El-Bermawy, M. (1993). DESIGN AND SYNTHESIS OF A PIPERAZINE DERIVATIVE AS A HIGH AFFINITY 5-HTIA RECEPTOR LIGAND. Zagazig Journal of Pharmaceutical Sciences, 2(2), 103-110. doi: 10.21608/zjps.1993.187356
MLA
Mohamed El-Bermawy. "DESIGN AND SYNTHESIS OF A PIPERAZINE DERIVATIVE AS A HIGH AFFINITY 5-HTIA RECEPTOR LIGAND", Zagazig Journal of Pharmaceutical Sciences, 2, 2, 1993, 103-110. doi: 10.21608/zjps.1993.187356
HARVARD
El-Bermawy, M. (1993). 'DESIGN AND SYNTHESIS OF A PIPERAZINE DERIVATIVE AS A HIGH AFFINITY 5-HTIA RECEPTOR LIGAND', Zagazig Journal of Pharmaceutical Sciences, 2(2), pp. 103-110. doi: 10.21608/zjps.1993.187356
VANCOUVER
El-Bermawy, M. DESIGN AND SYNTHESIS OF A PIPERAZINE DERIVATIVE AS A HIGH AFFINITY 5-HTIA RECEPTOR LIGAND. Zagazig Journal of Pharmaceutical Sciences, 1993; 2(2): 103-110. doi: 10.21608/zjps.1993.187356
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