STRUCTURE-ACTIVITY INVESTIGATION OF ATYPICAL ACRIDINE DERIVATIVES AS ANTIMICROBIAL AGENTS

Al-Ashmawi, Mohamed; El-Sadek, Mohamed; El-Bermawy, Mohamed; Kadry, Ashraf; Al-Sabbagh, Osama

doi:10.21608/zjps.1994.186740

STRUCTURE-ACTIVITY INVESTIGATION OF ATYPICAL ACRIDINE DERIVATIVES AS ANTIMICROBIAL AGENTS

Document Type : Original Article

Authors

¹ Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

² Dept. of Medicinal Chemistry, Faculty of Pharmacy, University of Zagazig, Zagazig , Egypt

³ Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University

⁴ Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Egypt

10.21608/zjps.1994.186740

Abstract

Although acridines and many tricylic compounds are known to possess potent antimicrobial activity, yet most of these compounds are either toxic (cannot be used systemically) or have other pharmacological activities. To develop safe and effective agents, we report the design and synthesis of nonclassical acridine derivatives. Biological evaluation of these acridine analogues showed a consistent structure-activity relationship. Some of these acridines showed potent antimicrobial activity, compound 22 exhibited MIC of 7 ug / mL.