SYNTHESIS OF NEW THIENO-[2,3-b]-PYRIDINE AND PYRAZOLO-5,4-b-PYRIDINE DERIVATIVES

Document Type : Original Article

Author

Chemistry Department, Faculty of Science, Zagazig University, Egypt.

Abstract

3-Cyano-4,6-dimethyl-2-pyridinethiol 1 was allowed to react with chloroacetone and hydrazine hydrate to give the corresponding thienopyridine derivative 2 and pyrazolopyridine derivative 5, respectively. Compound 2 reacted with aldehydes to yield 3a-3c. Reaction of compound 5 with thionyl chloride and arylidinemalononitriles gives 6 and 8a,b, respectively. Compound 6 reacted with benzil and p,p-dichlorobenzil to yield the corresponding benzilimine derivatives 7a,b.