SYNTHESIS OF NEW NICOTINOYL AMINO ACID DERIVATIVES

Document Type : Original Article

Author

Chemistry Department, Faculty of Science, University of Zagazig, Egypt.

Abstract

(S)-and/or (R)-(2-methyl-3-benzyloxycarbonyl-5-oxo-4-0xazolidinyl)-acetyl chloride, prepared from S-aspartic acid, which was reacted with 3-trimethyl stannylpyridine to give the corresponding pyridyl-ketone, then converted into enantiomeric (S)-and (R)-a- methylnicotinylalanine by hydrolysis with hydrochloric acid. Analogously, a-nicotinylalanine III was prepared from L-glutamic acid.