SYNTHESIS OF SOME PYRIMIDO-[1,6-a]- INDOLE OF POTENTIAL PHARMACOLOGICAL INTEREST

Document Type : Original Article

Authors

1 Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt

2 Pharmaceutical Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt

3 Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt

4 Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt

Abstract

The synthesis of some pyrimido-[1,6-a]- indole derivatives is described. Addition of dicyanomethylideneindoline (I) to various isocyanates gave 2-alkyl-3-imino-1-oxo-1,2,3,5- tetrahydropyrimido-[1,6-a]- indole-4-carbonitrile lla-h. The corresponding enaminonitriles Illa-h were obtained from II by reduction with sodium borohydride. Compounds IV-VIl were also obtained. Preliminary pharmacological screening revealed antipyretic, antiinflammatory and analgesic activities.

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