USE OF CERTAIN METAL IONS FOR THE DETERMINATION OF INDOMETHACIN

Document Type : Original Article

Authors

1 Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University. Zagazig. Egypt.

2 Department of Analytical Chemistry, Faculty of Pharmacy, University of Zagazig, Egypt.

3 Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt

4 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Zagazig, Egypt.

5 National Organization for Drug Control and Research, Giza, Egypt.

Abstract

A simple and accurate method was described for the quantitative determination of indomethacin using Ag+ and Cu2+ ions. Indomethacin was precipitated from its neutral alcoholic solution by standard solutions of silver nitrate and copper acetate followed by determining the resulted slats using atomic absorption spectroscopy and colorimetric techniques. The optimum conditions for silver and copper indomethacin slat formations have been carefully studied. The molar ratio of the reactants in the case of copper was ascertained by atomic absorption spectroscopy and by formation of copper sodium diethyldithiocarbamate and was found to be 2:1 (indomethacin: cu+2). Both of the developed methods were compared with the previous official methods to indicate high accuracy (t-test) and reproducibility (f-test).

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