DETERMINATION OF PHENOBARBITONE IN TWO AND THREE COMPONENTS FORMULATIONS BY FIRST AND SECOND DERIVATIVE ULTRAVIOLET SPECTROPHOTOMETRY

Document Type : Original Article

Authors

1 MiST Pharmacy. Menia El-Kamh, Sharkia, Eqypt.

2 Chemistry Department, Girls College (Scientific Departments) Riyadh, Saudi Arabia

Abstract

Phenobarbitone has been determined in a ternary mixture with oxyphenonium bromide and meprobamate (mixture A) and in binary mixtures with paracetamol (mixture B) or acetylsalicylic acid (mixture C) using derivative spectrophotometry applying zero-crossing technique of measurement. The combining active ingredients have also been determined. The procedures were proved using laboratory prepared mixtures and their utility in assay of pharmaceutical dosage forms were also presented.