SYNTHESIS OF SOME PYRIMIDO-[4', 5' : 4,5]-PYRIMIDO-[ 1,6-a ]INDOLE OF POTENTIAL ANTIINFLAMMATORY AND ANTIPYRETIC ACTIVITIES

Document Type : Original Article

Authors

1 Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt

2 Pharmaceutical Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt

3 Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt

4 Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt

Abstract

The synthesis of 12,12a-dihydropyrimido-[4',5' : 4,5]-pyrimido-[1,6-a]-indole-1,6[ 2H, 5H]-dione is described. Treatment of enaminonitriles I with chloroacetyl chloride afforded the tetracyclic compounds II. In contrast compound I with nuorophenyl group at position 2 gave N-chloroacetylamino derivatives III which underwent cyclization either by acid or base. Preliminary Pharmacological screening of some compounds showed significant antiinflammatory and antipyretic activities.

Files

Share

How to cite

Statistics