Bradykinin (BK) and three of its analogs, (DAla)7 BK, (Gly)7 BK and (Pro)6 BK were synthesized by the continuous flow method. Polystyrene-polyethylene glycol graft copolymer was employed as modified polymeric support. The effect of the replacement of Pro7 by DAla, Gly and Ser6 by Pro on the 3--->1 intramolecular hydrogen bond present in BK chain, between the carbonyl oxygen of Ser6 and the amide proton of Phe8 bridging Pro7, was investigated. Although there are remarkable changes in the CD spectral features of these analogs compared to that of BK, they exhibited comparable biological activities.
Abdel-Rahman, S. (1995). SYNTHESIS, CIRCUILAR DICHROISM AND BIOLOGICAL ACTIVITIES OF BRADYKININ AND SOME ANALOGS. Zagazig Journal of Pharmaceutical Sciences, 4(1), 18-24. doi: 10.21608/zjps.1995.186310
MLA
Somaya Abdel-Rahman. "SYNTHESIS, CIRCUILAR DICHROISM AND BIOLOGICAL ACTIVITIES OF BRADYKININ AND SOME ANALOGS", Zagazig Journal of Pharmaceutical Sciences, 4, 1, 1995, 18-24. doi: 10.21608/zjps.1995.186310
HARVARD
Abdel-Rahman, S. (1995). 'SYNTHESIS, CIRCUILAR DICHROISM AND BIOLOGICAL ACTIVITIES OF BRADYKININ AND SOME ANALOGS', Zagazig Journal of Pharmaceutical Sciences, 4(1), pp. 18-24. doi: 10.21608/zjps.1995.186310
VANCOUVER
Abdel-Rahman, S. SYNTHESIS, CIRCUILAR DICHROISM AND BIOLOGICAL ACTIVITIES OF BRADYKININ AND SOME ANALOGS. Zagazig Journal of Pharmaceutical Sciences, 1995; 4(1): 18-24. doi: 10.21608/zjps.1995.186310
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