PMR DETERMINATION OF PRAZIQUANTEL

Document Type : Original Article

Authors

1 Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt.

2 Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt

3 Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt.

4 Department of Chemistry, Faculty of Science, Zagazig University, Egypt.

Abstract

Pmr techniques have been used for the determination of praziquantel as sum integeral of the cyclohexane protons as multiplet that appear at 1.1-2 ppm and as compared to the sum integeral of the 1,4-disubstituted aromatic protons system as doublet of doublet that appear at 7.5-8.5 ppm using N,N-dimethylaminobenzaldehyde as internal standard. The obtained results shows % recovery of mean average 100.39. The method is valid for the determination of praziquantel in tablet and in presence of its induced degradation products.

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