ALTERED HEPATIC FUNCTION CONSEQUENT TO IVERMECTIN TREATMENT IN RAMS

Hassan, Hany; Nasser, Mohamed; Abd El-Malak, Mary; Emara, Samira

doi:10.21608/zjps.1995.185631

ALTERED HEPATIC FUNCTION CONSEQUENT TO IVERMECTIN TREATMENT IN RAMS

Document Type : Original Article

Authors

¹ Animal Reproduction research Institute, P.O. 12556 EL-Haram, Giza, Egypt

² Faculty of Veterinary Medicine, Tanta University, Kafr El Sheikh branch, Egypt

³ Animal Reproduction Research Institute, P.O box 12556, El-Haram, Giza, Egypt,

10.21608/zjps.1995.185631

Abstract

This work was carried out on twelve clinically healthy adult Barki rams, divided into two equal groups. The first one was served as control and each animal of the second group was injected subcutaneously with one dose of 0.2 mg ivermectin /Kg body weight. Ivermectin treated group revealed a significant elevation in blood serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, isocitrate dehydrogenase, gamma glutamyl transferase, arginase, sorbitol dehydrogenase and total cholesterol. Meanwhile, ivermectin did not evoke any significant alteration in serum urea and creatinine levels. A very important conclusion that appears to be surfacing from the previous results is that this study represent further image of the hazardous effect of ivermectin in rams. Ivermectin inflected deleterious effects reflected as hepatic dysfunction.