MICRODETERMINATION OF SOME ANALGESICS AND ANTI-INFLAMMATORY DRUGS USING SILVER NITRATE

Document Type : Original Article

Authors

1 Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

2 Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig. Egypt

3 Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Abstract

A simple and accurate method is described for the microquantitative determination of mefenamic acid, flufenamic acid and flurbiprofen. The method is based on the reaction of the above cited drugs with a silver nitrate solution in a neutral alcoholic medium. The formed precipitate is quantitatively determined directly or indirectly through the silver content of the precipitate formed or the residual unreacted silver ions in the filtrate by atomic absorption spectrophotometry. The results obtained in both procedures either in their pure form or in their pharmaceutical formulations are accurate and precise. The stoichiometric relationship of the reaction was studied using Job's continuous variation method, it was found to be (1:1) drug: Ag+ for the above drugs.

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