DETERMINATION OF NORFLOXACIN AND OFLOXACIN THROUGH CHARGE TRANSFER COMPLEXATION

Document Type : Original Article

Authors

1 Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt

2 Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.

3 Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Egypt.

Abstract

A spectrophotometric method was described for the determination of the antibacterial quinolone derivative, norfloxacin and ofloxacin. Chloranilic acid was utilized for their determination, forming charge transfer complex with Amax. 517 and 520 for norfloxacin and ofloxacin, respectively. The optimum conditions of the reaction were discussed. The proposed method was applied for the determination of Noroxin and Tarivid tablets with means percentage accuracies, 100.7 ± 2.08 and 102.13 ± 2.08, respectively. Statistical analysis showed no significant difference between the proposed and official methods.

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