COMPARATIVE IN-VITRO STUDY OF THE EFFICACY OF NEW QUINOLONES VERSUS NALIDIXIC ACID AND NITROFURANTION AGAINST BACTERIAL UROPATHOGENS

Bacteriological examination of 161 patients with urinary tract infections enrolled in the study, revealed that Pseudomonas aeruginosa was the commonest organism isolated from urine samples in all patients (36%) followed by Staphylococcus aureus (21%), Klebsiella pneumoniae (16.8%), Escherichia coli (12.4%). Other isolates included Streptococus pneumoniae 4.3%), Proteus mirabilis (3.7%), Staphylococus epidermidis (1.9%), Streptococcus faecalis (2.5%) and Enterobacter aerogenes (1.2%). Antimicrobial susceptibility patterns highlightened the spectra and efficiencies of the tested antimicrobials. About 86, 80, 74, 24 and 15% of the isolates were sensitive to ciprofloxacin, norfloxacin, pefloxacin, nalidixic acid and nitrofurantoin, respectively. There was an increased emergence of antimicrobial resistant organisms against many agents (multidrug resistance). Nine, two and six isolates of Ps. aeruginosa, E. coli and K. pneumoniae were resistant to 5,4 and 2 drugs respectively. Meanwhile, 5,2 and one isolates of S. aureus, St. species and S. epidermidis were resistant to 3,2 and 5 drugs, respectively. Because of the superior efficacy, broader spectra, proper pharmacokinetics and lower side effects, this study recommends the necessity for use the recent quinolone antibacterials such as ciprofloxacin, norfloxacin or pefloxacin in the treatment of urinary tract infections.