SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN FLURBIPROFEN DERIVATIVES

Document Type : Original Article

Authors

1 Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt

2 Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt

3 Department of Medicinal Chemistry, Faculty of Pharmacy, University of Zagazig, Egypt.

Abstract

The synthesis of several flurbiprofen amides and hydrazones is described. Structures of the new compounds were substantiated by microanalytical and spectroscopic data. Five representative compounds were subjected to preliminary pharmacological screening which revealed that three of them exhibited superior analgesic, antipyretic and anti-inflammatory activities compared to flurbiprofen.

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