SPECTROSCOPIC METHODS FOR THE DETERMINATION OF FLURBIPROFEN AND TIAPROFENIC ACID

Document Type : Original Article

Authors

1 Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

2 Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig. Egypt

3 Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Abstract

Flurbiprofen and tiaprofenic acid reacted easily and quantitatively with copper acetate forming bluish green precipitates. The drugs were determined colourimetrically by extracting the formed precipitates in chloroform and measuring the absorbance at 686 nm for flurbiprofen and 696 nm for tiaprofenic acid.
To improve the sensitivity of the method the formed precipitates of these drugs with copper were dissolved in the least amount of dilute ammonia and the copper content was determined via reaction with sodium diethyldithiocarbamate. The formed yellow colour was measured at 447 nm. Flurbiprofen was also estimated using atomic absorption spectrometer procedure through the determination of the copper content of the precipitate. The optimum conditions for precipitation have been carefully studied. The molar ratio of the reactants were ascertained. Statistical analysis of the results obtained were compared with the official methods.
Results obtained were of equal accuracy and reproducibility. The proposed methods were successfully applied for determination of flurbiprofen and tiaprofenic acid in their pharmaceutical dosage forms and the results obtained were in good agreement with those of the official methods.

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