CRECTROPHOTOMETRIC DETERMINATION OF PHENYLBUTAZONE AND OXYPHENBUTAZONE THROUGH CONDENSATION WITH P-DIMETHYLAMINOBENZALDEHYDE

Document Type : Original Article

Authors

1 Pharmacy Institute, Bonn University, Germany

2 Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University. Zagazig. Egypt.

3 Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt

Abstract

P-Dimethylaminobenzaldehyde is used for colorimetric determination of phenylbutazone and oxyphenbutazone both in pure form and in their tablets. The reaction proceeds via first formation of aldol intermediate which suffers aminolysis by piperidine with subsequent elimination to afford intensive and stable colored disubstituted styrene. Beer's law is obeyed in the range of 0.08-0.4 mg mg-1 for phenylbutazone and 0.08-0.24 mg ml for oxyphenbutazone.

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