PHYTOCHEMICAL STUDY AND BIOASSAY OF SOME CONSTITUENTS FROM HELIOTROPIUM BACCIFERUM FORSSK

Document Type : Original Article

Authors

1 Department of Pharmacognosy, Faculty of Pharmacy, University of Zagazig, Egypt.

2 Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

3 Pharmacognosy Department, Faculty of Pharmacy, University of Zagazig , Zagazig , Egypt

4 Department of Pharmacognosy, Faculty of Pharmacy University of Zagazig, Egypt

5 Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.

Abstract

Heliotropium bacciferum forssk (Boraginaceae) was found to contain heleurine N-oxide, heliotrine N-oxide and europine N-OXide as well as B-amyrin, B-sitosterol, B-sitosterol-O-glucoside. A new preparative HPLC method for the isolation of Pas N-oxides was developed. The expected cytotoxic activities were determined by the brine shrimp bioassay to measure their toxic activities and potential cytotoxicity.

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