STABILITY OF DIRECTLY COMPRESSED FLUCONAZOLE TABLETS PREPARED BY SUPER DISINTEGRANTS

Salama, Mohamed; El-Ghamry, Hanaa

doi:10.21608/zjps.1997.184945

STABILITY OF DIRECTLY COMPRESSED FLUCONAZOLE TABLETS PREPARED BY SUPER DISINTEGRANTS

Document Type : Original Article

Authors

Mohamed Salama ¹
Hanaa El-Ghamry ²

¹ Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University Zagazig - Egypt.

² Department of Pharmaceutics, and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.

10.21608/zjps.1997.184945

Abstract

Fluconazole as drug is used for the treatment of fungal infections, prepared as directly compressed tablets using super disintegrant cross-linked PVP (Polyplasidone XL) alone and in combination with different concentrations of cross-linked carboxymethy1 cellulose (Ac-Di-Sol). The prepared tablets were physically evaluated by subjecting to several tests, friability, hardness, disintegration time and dissolution rate. The chosen formulae with the best characteristics was stored at room temperature for one year and re-evaluated for its same characteristics. The results indicated that the tablets prepared with combination of 2.5% cross-linked CMCNA and 6% cross-linked PVP demonstrated good reproducible characteristics prior to and after storage.