Within the scope of evaluating transparent oil/water (TOW) gels as dermatological vehicles, the anti-inflammatory and analgesic agent Naproxen (NA) was incorporated in a transparent oil-water gel containing two emulsifying agents (Emulgin B3 and Cetiol HE), an oily liquid (isopropylpalmitate) and water. The release rate of NA from the TOW gel formulation through a cellophane membrane into phosphate buffer (pH 6) at 37°C was studied. The percutaneous absorption in rabbits was evaluated and compared with the absorption from a hydrogel and from a hydrophilic base formulation. The area under the curve and the Cmax values in plasma were significantly higher for the TOW gels in comparison with other formulations after single application. A good correlation was observed between the in-vitro and in-vivo data.
EL-Sayed, M. (1998). IV -VITRO AND IN -VIVO AVAILABILITY OF NAPROXEN FROM TRANSPARENT OIL/ WATER GELS IN COMPARISON TO SOME CONVENTIONAL TOPICAL BASES. Zagazig Journal of Pharmaceutical Sciences, 7(1), 105-110. doi: 10.21608/zjps.1998.184820
MLA
Mohamed M EL-Sayed. "IV -VITRO AND IN -VIVO AVAILABILITY OF NAPROXEN FROM TRANSPARENT OIL/ WATER GELS IN COMPARISON TO SOME CONVENTIONAL TOPICAL BASES", Zagazig Journal of Pharmaceutical Sciences, 7, 1, 1998, 105-110. doi: 10.21608/zjps.1998.184820
HARVARD
EL-Sayed, M. (1998). 'IV -VITRO AND IN -VIVO AVAILABILITY OF NAPROXEN FROM TRANSPARENT OIL/ WATER GELS IN COMPARISON TO SOME CONVENTIONAL TOPICAL BASES', Zagazig Journal of Pharmaceutical Sciences, 7(1), pp. 105-110. doi: 10.21608/zjps.1998.184820
VANCOUVER
EL-Sayed, M. IV -VITRO AND IN -VIVO AVAILABILITY OF NAPROXEN FROM TRANSPARENT OIL/ WATER GELS IN COMPARISON TO SOME CONVENTIONAL TOPICAL BASES. Zagazig Journal of Pharmaceutical Sciences, 1998; 7(1): 105-110. doi: 10.21608/zjps.1998.184820
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