Document Type : Original Article
Authors
1
Dept. of Medicinal Chemistry, Faculty of Pharmacy, University of Zagazig, Zagazig , Egypt
2
Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt
3
Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt
4
Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig. Egypt
Abstract
The synthesis of some novel non- carboxylic heterocyclic derivatives of flurbiprofen such as pyrazole , pyrrole , oxadiazole, oxadiazines, and triazoles, is described. Structure of the new compounds was elucidated by spectroscopic data and microanalysis. Three representative compounds were tested for analgesic, antipyretic, and anti-inflammatory activities. The pyrazole derivative VIII displayed greater antipyretic activity but lower analgesic and anti-inflammatory activities compared to flurbiprofen. However, the other two compounds were , in general, less potent than flurbiprofen.
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