SPECTROPHOTOMETRIC ESTIMATION OF SOME NITROGENOUS PHARMACEUTICAL COMPOUNDS BY CHARGE TRANSFER COMPLEXATION

Ayad, Magda; Khalil, Hawa; El-Henawee, Magda; Hosny, Mervat

doi:10.21608/zjps.1999.184167

SPECTROPHOTOMETRIC ESTIMATION OF SOME NITROGENOUS PHARMACEUTICAL COMPOUNDS BY CHARGE TRANSFER COMPLEXATION

Document Type : Original Article

Authors

¹ Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University. Zagazig. Egypt.

² Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

³ Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig. Egypt

10.21608/zjps.1999.184167

Abstract

Three simple and sensitive colorimetric methods have been developed for the estimation of trazodone, timolol and piribedil through electron transfer complexation reaction. The methods involve the reaction of these drugs as p-donors with either n-electron acceptors P-chloronilic acid (PCA) and tetracyano-quinodimethane (TCNQ) and iodine as acceptor to give a stable and highly coloured radical anion. The coloured products were measured spectrophotometrically. The optimization of the different experimental conditions has been studied. The suggested methods were applied to assay the tested compounds in their pharmaceutical preparations. The results obtained agreed well with the reference methods.