NUCLEOPHILIC CLEAVAGE OF N-SUBSTITUTED -3- OXO- 2,3- DIHYDRO BENZO (d) - 1,2 -THIAZOLE-1,1-DIOXIDE WITH HYDRAZINE HYDRATE

Document Type : Original Article

Authors

1 Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

2 Department of Medicinal Chemistry, Faculty of Pharmacy, University of Zagazig, Zagazig -Egypt.

Abstract

The reaction profile of certain 2-substituted-3-oxo-2,3- dihydrobenzo (d)-1,2- thiazole-1,1-dioxide (N-substitued saccharines) with hydrazine hydrate is described. It was found that the steric hindrance displayed by the substituents at position-2 has a profound effect on reaction rate. Some of the synthesized compounds were subjected to preliminary antimicrobial activity.

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