SYNTHESIS OF SOME NEW QUINOLINE DERIVATIVES OF POTENTIAL ANTIMICROBIAL ACTIVITY

Document Type : Original Article

Authors

1 Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

2 Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt

3 Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig. Egypt

4 Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt

Abstract

A series of quinolinoxymethyl triazole (5), oxadiazole (6,8), isoxazolidin-3,5-diones (10), pyrazolidin-3,5-diones (11a,b) and other related pyrimidin-2,4,6-triones (12,) and pyrimidin-4,6-dione-2-thiones (12a) were synthesized. Four of the synthesized compounds were tested for antimicrobial activity; two of them displayed high activity against a variety of bacterial strains.

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