BINUCLEOPHILIC REACTION IN SYNTHESIS OF PYRIDOPYRROLOPYRAZINES AS POTENTIAL ANTIMICROBIAL AGENTS

Document Type : Original Article

Author

Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Abstract

Synthesized from dichloromaleimides and 5-bromo -2,3-diaminopyridine as binucleophil, novel pyridopyrrolopyrazines have been described. The synthetic approach involved application of reductive nitrosation reaction recently developed in our laboratories.