SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME NEW ARYLSULPHONYLUREA AND THIOUREA DERIVATIVES

Document Type : Original Article

Authors

1 Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt

2 Department of Pharmacology, Faculty of Veterinary Medicine, University of Mansoura, Egypt.

Abstract

Certain arylsulphonylureas and thioureas derivatives were synthesized to be tested as hypoglycemic and antimicrobial agents in comparison with glibinclamide and sulphanilamide, respectively. The interaction of 3-chloro-2-p-substitutedphenylamino-N-(4-sulphamoylphenyl) maleimide (2) or its carbamate derivatives (3) with phenylisocyanate, phenylisothiocyanate or with appropriate amine afforded the target products. Some of the new compounds showed considerable hypoglycemic and antimicrobial activities.