Document Type : Original Article
Authors
1
Biochemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
2
Biochemistry Department, Faculty of Pharmacy, University of Zagazig, Egypt
3
Biochemistry Department, Faculty of Pharmacy, University of Suez Canal, Egypt
4
Biochemistry Department, Faculty of Pharmacy, University of Zagazig , Egypt
Abstract
Diabetes mellitus is a disease characterized by chronic hyperglycemia and many metabolic disturbances. The present work was undertaken to study certain iron related parameters (serum iron, total iron binding capacity, ferritin and transferrin) in diabetic individuals (type I and II). Also to correlate the degree of glycemic control by estimating glycated hemoglobin, lipogram pattern (total cholesterol, triacylglycerols, high and low density lipoprotein cholesterol) and lipid peroxidation (MDA). This may be of value in elucidation of many metabolic disturbances in diabetes mellitus. A total of 70 diabetic patients (25 females, 5 males, age 40±Y of IDDM) and 32 females, 8 males, age 45 ± 7 Y of NIDDM) were participating in this study. They were selected from outpatient clinic, Zagazig University Hospital. 15 healthy volunteers (10 females and 5 males, age 40 ± 5 Y) were chosen as a control group. Full history and complete clinical examination for each patient and control were done. The present data showed that glycated hemoglobin, lipid peroxide and ferritin were significantly increased in both diabetic groups in comparison to controls. Transferrin demonstrated significant reduction, while serum iron and total iron binding capacity were non significantly changed. Total-, low density lipoprotein cholesterol and triacylglycerols showed significant increase, high density lipoprotein however demonstrated significant decrease in comparison to control group. These findings revealed that, poorly controlled diabetics usually suffer from hyperferritinemia and an increase in oxidation derived products, but we could not find a correlation between lipid peroxidation and iron homeostasis or glycated hemoglobin.
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