Two series of 8-chloro-2, 3, 4, 5,10,11-hexahydro-11-substituted-1H-dibenzob,e 1,4 diazepine-1-ones and their3,3- dimethyl analogs were prepared via internal Mannich reaction of 3-[(2- amino-4- chlorophenyl) amino] -2-cyclohexen-1-one and its 5,5-dimethyl analog, respectively, with different aldehydes at room temperature. The synthesized compounds were evaluated for their clozapine-like properties. The structures of the novel compounds were confirmed using elemental analyses and different spectroscopic methods. Pharmacological evaluation of some of the synthesized dibenzodiazepine derivatives revealed that compounds 4 and 17 (having 4-bromophenyl moiety) exhibited a high antipsychotic and sedative properties.
El-Sabbagh, O., & Abd-El Alim, A. A. (2000). SYNTHESIS OF NEW NONCLASSICAL DIBENZODIAZEPINE DERIVATIVES AS POTENTIAL ANTIPSYCHOTIC AGENTS. Zagazig Journal of Pharmaceutical Sciences, 9(1), 9-16. doi: 10.21608/zjps.2000.181618
MLA
Osama El-Sabbagh; Abd-El Alim Abd-El Alim. "SYNTHESIS OF NEW NONCLASSICAL DIBENZODIAZEPINE DERIVATIVES AS POTENTIAL ANTIPSYCHOTIC AGENTS". Zagazig Journal of Pharmaceutical Sciences, 9, 1, 2000, 9-16. doi: 10.21608/zjps.2000.181618
HARVARD
El-Sabbagh, O., Abd-El Alim, A. A. (2000). 'SYNTHESIS OF NEW NONCLASSICAL DIBENZODIAZEPINE DERIVATIVES AS POTENTIAL ANTIPSYCHOTIC AGENTS', Zagazig Journal of Pharmaceutical Sciences, 9(1), pp. 9-16. doi: 10.21608/zjps.2000.181618
VANCOUVER
El-Sabbagh, O., Abd-El Alim, A. A. SYNTHESIS OF NEW NONCLASSICAL DIBENZODIAZEPINE DERIVATIVES AS POTENTIAL ANTIPSYCHOTIC AGENTS. Zagazig Journal of Pharmaceutical Sciences, 2000; 9(1): 9-16. doi: 10.21608/zjps.2000.181618
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