UTILIZATION OF α-BROMOCYCLIC DIKETONES AS MICHAEL DONORS FOR THE SYNTHESIS OF COUMARIN ANALOGUES

El-Sawah, Magdy; El-Bermawy, Mohamed; Abdel-Aal, Eatedal; Kadry, Azza; Al-Ashmawi, Mohamed

doi:10.21608/zjps.2000.181616

UTILIZATION OF α-BROMOCYCLIC DIKETONES AS MICHAEL DONORS FOR THE SYNTHESIS OF COUMARIN ANALOGUES

Document Type : Original Article

Authors

¹ Department of Pharmaceutical Org. Chem., Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

² Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

³ Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.

10.21608/zjps.2000.181616

Abstract

Coumarin nucleus is of biological importance. Anticoagulants which are very common contain coumarin moiety. Herein we describe a facile method to prepare this valuable nucleus. α-Bromocyclic diketones were used as Michael donors and each reacted with various substituted acrylonitriles, which behaved as Michael acceptors. Elimination of hydrobromic acid leads to the formation of the target compounds (17-30) in reasonable yields.