The effect of oral administration of quercetin (QRT) (25 mg/kg) on an experimentally Ibuprofen- induced ulcer was studied in rats. The results of gross appearance and scanning electromicrographs of the mucous membrane and superficial cells of the stomach revealed that the quercetin reduced the damage of submucosal superficial cells. Differential scanning calorimetry, X-ray diffractometer, IR spectroscopy, solubility and partitioning studies elucidated the absence of any interaction between the two compounds and also the physical compatibility of ibuprofen (IP)-quercetin combination. It is concluded that ibuprofen and quercetin can be pharmaceutically co-formulated or co-administrated with the aim of reducing the gastrointestinal adverse effects of ibuprofen.
Abdel Mohsen, M., El-Badry, M., Soliman, O. (2001). 'IBUPROFEN-QUERCETIN COMBINATION ASA NOVEL PHARMACEUTICAL COMPATIBLE SYSTEM', Zagazig Journal of Pharmaceutical Sciences, 10(1), pp. 29-33. doi: 10.21608/zjps.2001.181592
VANCOUVER
Abdel Mohsen, M., El-Badry, M., Soliman, O. IBUPROFEN-QUERCETIN COMBINATION ASA NOVEL PHARMACEUTICAL COMPATIBLE SYSTEM. Zagazig Journal of Pharmaceutical Sciences, 2001; 10(1): 29-33. doi: 10.21608/zjps.2001.181592
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