SPECTROPHOTOMETRIC AND TITRIMETRIC ESTIMATION OF CEFTRIAXONE.

Four simple rapid sensitive and accurate methods (A, B, C and D) for micro- and semimicro-determination of ceftriaxone in pure and dosage forms are developed. Method A is based on drug reaction with ammonium molybdate in acidified solution under heat treatment, the blue colour developed is measured at 697 nm. Beer's law is obeyed for 40-240 µg ml^-1 ceftriaxone. Method B is based on the oxidation with potassium permanganate in presence of sulphuric acid at room temperature. The decrease in permanganate colour (ΔA) is measured at 524.8 nm.. Beer's law is obeyed for 5-40 µg.ml^-1. Method C is based on the direct titration against potassium bromate in hydrochloric acid medium using methyl red indicator (irreversible ind.).While method D is based on the oxidation of ceftriaxone with iron(III) in acidic medium .the liberated iron (II) reacts with 1,10-phenanthroline. The ferroin complex is colorimetrically measured at 2 max 510 nm against reagent blank. Beer's law is obeyed for 1-9 µg.ml^-1. The developed methods are successfully applied for determination of the cited drug in pharmaceutical product.