SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF SOME NOVEL THIENOPYRIMIDINE DERIVATIVES

Abd El-Samii, Zakaria; El-Feky, Said; Abedel-Fattah, Hanan; Soliman, Mahmoud

doi:10.21608/zjps.2004.177894

SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF SOME NOVEL THIENOPYRIMIDINE DERIVATIVES

Document Type : Original Article

Authors

¹ Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

² Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

10.21608/zjps.2004.177894

Abstract

4-Chloro-5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidine (3) was reacted with 4-aminoacetophenone in ethanol to give 4(4- acetylanilino)5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidine (4). Compound 4 was used as a key intermediate for the synthesis of several pyrazoles 6-8, pyridones 13, 14, thiazoles 15, 17 and thiazolidinones 18, 19. On the other hand, compound 3 was fused with ethyl 2-amino-4,5,6,7-tetrahydrobenzofbthiophene-3-carboxylate and anthranilic acid to give compound 9 and 10 respectively. Compound 14b showed the same antiinflammatory activity as that of the reference drug dichlofenac sodium.