SYNTHESIS, ANTIMICROBIAL AND ANTIVIRAL ACTIVITY OF 1,8- DIOXODECAHYDROACRIDINE DERIVATIVES

10-(4-Hdroxy phenyl)-9-4-substituted phenyl)-1,8-dioxo-1.2.3.4,5,6,7,8,9,10-decahydroacridine and  their 3,3,6,6,-tetramethyl derivatives (II_1-4) have been prepared by reacting 3-(4-hydroxypheny lamino)-2-cyclohexenone or its 5,5-dimethyl derivative (I_1,2 ) with the appropriate araldehyde. Alkylation of II_1-4 with ethyl bromoacetate gave the corresponding esters III_1-4 which were condensed with hydrazine hydrate to produce hydrazides IV_1-4 .These hydrazides underwent condensation with either 2.5-hevanedione to afford the pyrrole derivatives V_1-4, or aromatic aldehydes to give the hydrazone derivatives VI _1-20. Cyclo-condensation of some of the obtained hydrazones VI_{1,3,5,11-13,15-18} with thioglycolic acid afforded the corresponding thiazelidinones VII_1-10 .The antimicrobial activity for thirteen new compounds against either Gram positive or negative bacteria and fungi showed that compounds IV were the most active ones against Bacillus subtilus Moreover, the antiviral activity for twenty Compound  performed on Vero cells against Rinderpest virus revealed that compounds IV₃ , VI₁₃ and VII₆, caused reduction the cytopathic effect of virus: by 25, 33 and 50 %, respectively at a dose of 1000 µg/ml.