INCREASING SENSITIVITY OF COLORIMETRIC DETERMINATION OF BASIC DRUGS THROUGH ION PAIR COMPLEX FORMATION

Document Type : Original Article

Authors

1 Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt

2 Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig. Egypt

Abstract

The method describes a colorimetric procedure for determination of some vasoacting drugs namely, domperidone, dipyridamole, and cinnarizine. In this procedure, metanil yellow and methyl orange were utilızed in the determination of the concerned compounds by forming ion pair complex in aqueous solution at acidic pH's.Upon extraction of the ion pair into methylene chloride, the yellow extract showed absorption maxima at 413 and 425 nm for metanil yellow and methyl orange, respectively .Sensitivity has been increased nearly two times with metanil yellow and nearly six times with methyl orange on acidification of the methylene chloride extract with acidified ethanol which resulted in conversion of the yellow organic extract into magenta red color with absorption maxima at 541 nm and 525 nm for metanil yellow and methyl orange, respectively The procedure was applied for the determination of these compounds in their formulations. Statistical analysis showed no significant difference between the proposed method and official or reported methods.

Files

Share

How to cite

Statistics