New O-aminonitriles (enaminonitriles) namely, pyrimido[1,6-a] indole were prepared by addition of 2-dicyanome thylidinoindoline-obtained from oxindole- to various isothiocyanates. The obtained enaminonitriles were acylated using chloroacetylchloride yielding methylchloride derivatives of the condensed pyrimidines, pyrimido (4,5 :4,5] pyrimido[1,6-a] indole. The chlorine atom was substituted by different amines or condensed with thiourea and the formed salts were hydrolyzed to give mercaptoalkyl compounds. Some of the prepared compounds were tested for their analgetic activities.
Lashine, E. (1992). NEW CONDENSED PYRIMIDINES AS POTENTIAL ΑNALGETICS. Zagazig Journal of Pharmaceutical Sciences, 1(2), 85-93. doi: 10.21608/zjps.1992.169730
MLA
El-Sayed Lashine. "NEW CONDENSED PYRIMIDINES AS POTENTIAL ΑNALGETICS". Zagazig Journal of Pharmaceutical Sciences, 1, 2, 1992, 85-93. doi: 10.21608/zjps.1992.169730
HARVARD
Lashine, E. (1992). 'NEW CONDENSED PYRIMIDINES AS POTENTIAL ΑNALGETICS', Zagazig Journal of Pharmaceutical Sciences, 1(2), pp. 85-93. doi: 10.21608/zjps.1992.169730
VANCOUVER
Lashine, E. NEW CONDENSED PYRIMIDINES AS POTENTIAL ΑNALGETICS. Zagazig Journal of Pharmaceutical Sciences, 1992; 1(2): 85-93. doi: 10.21608/zjps.1992.169730
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