TOXICOLOGICAL EFFECTS OF THE ORAL ADMINISTRATION OF THE AQUEOUS EXTRACT FROM CALLIGONUM COMOSUM TO RATS

Document Type : Original Article

Authors

Dept of Vet. Med., College of Agric. and Vet. Med., King Saud Univ., Qassim, Bureidah, Saudi Arabia

Abstract

Adult male Wistar rats were given daily oral doses of the lyophilized aqueous extract of Calligonum comosum at the rate of 400 mg/kg (b.wt.) for 4 weeks. The biochemical changes included a significant increase in the levels of serum Calcium and SUN (P < 0.05). On the other hand, decreased values were noted in the levels of serum albumin (P < 0.01). Haematological changes showed increased lymphocyte count (P < 0.05), whereas, decreases were noted in the levels of Hb (P < 0.01) and total WBCS count (P < 0.05), in addition to panleucocylopenia (P < 0.05) involving all the granulocytes and the monocytes ( P < 0.001).