PYRROLIZIDINE ALKALOIDS OF CERINTHE GLABRA MILLER (BORAGINACEAE)

Document Type : Original Article

Author

Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt

Abstract

The pyrrolizidine alkaloids of Cerinthe glabra Miller (total yield 0.3 mg/g dry weight) was investigated by capillary GLC and GLC-MS in combination with retention indices. Six pyrrolizidine alkaloids were identified for the first time in this plant, of which 5 unambiguously identified by comparing their specific retention indices and mass fragmentation with those of authentic alkaloids and literature data. Lycopsamine, 7-acetyllycopsamine and 3'-acetyllycopsamine were the prominent alkaloids in the reduced extract, Supinine, 3,7-diacetyllycopsamine and the tentatively identified 7-hydroxymethylbutyryl-9-viridifloryl-retronecine were detected as minor constituents.