APPLICATION OF ACID-DYE COMPLEXATION METHOD FOR THE EXTRACTIVE- SPECTROPHOTOMETRIC DETERMINATION OF MOEXIPRIL-HCI

Document Type : Original Article

Authors

1 Medicinal Chemistry Department, Faculty of Pharmacy. Zagazig University, Zagazig.

2 Pharmaceutical Chemistry Department, Faculty of Pharmacy, Suez canal University, Ismaila, Egypt

Abstract

New spectrophotometric procedures have been established for the assay of moexupnl-HCI n bulk form, in pharmaceutical formulations. The procedures are based on the reaction between the examined drug and bromocresol purple (HCP), bromophenol blue (BPB), and bromothymol blue (BTB) in aqueous acidic medium producing an ion-pair complexes extracted in chloroform and measured at the optimum wavelengths (405, 410, and 415 mm for MOEX-BCP, MOEX-BTB, and MOEX-BPB, respectively). Reaction conditions were studied and optimized to obtain the maximum colour intensity .The reactions were extremely rapid at room temperature and the absorbance values remains unchanged for 48 h The proposed methods have been applied successfully for the analysis of the drug in pure form and in its dosage forms. Statistical comparison of the results with those obtained by second derivatives spectrophotometric method shows excellent agreement and indicates no significant difference in accuracy and precision.

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