OCULAR BIOAVAILABILITY OF ENROFLOXACIN-CYCLODEXTRIN COMPLEXES FROM CERTAIN OPHTHALMIC PREPARATIONS IN RABBITS EYES

Abd El-Aleem, Hamdy; Ramadan, Esmail; Soliman, Osama; Kheira, Samy; El-Dahhan, Marwa

doi:10.21608/zjps.2006.169416

OCULAR BIOAVAILABILITY OF ENROFLOXACIN-CYCLODEXTRIN COMPLEXES FROM CERTAIN OPHTHALMIC PREPARATIONS IN RABBITS EYES

Document Type : Original Article

Authors

¹ Department of Pharmaceutics, Faculty of Pharmacy. Mansoura University, Mansoura, 35516, Egypt.

² Department of Pharmaceutics Faculty of pharmacy. Mansoura University, Mansour. 35516. Egypt.

³ Department of Microbiology, Faculty of Pharmacy. Mansoura University, Mansoura, 35516, Egypt.

10.21608/zjps.2006.169416

Abstract

The effect of inclusion complexes of enrofloxacin (Enr) with cyclodextrins (CyDs): hydroxypropyl beta-cyclodextrin (HP-β -CYD) and beta-cyclodextrin (β -CyD) was studied. These complexes were prepared in a molar ratio (1:2). The ophthalmic gels [sodium carboxymethyl cellulose (sod CMC), sodium alginate] and ointments (emulsion, absorption and water soluble bases) were prepared using 0. 5% of the drug or equivalent amounts of its complexes with HP- β -CyD or β -CyD. The ocular disposition of the drug in rabbit's eyes has been studied.
The obtained results revealed that, all tested formulations provided the highest C_max of the drug in conjunctiva followed by Cornea, iris-ciliary body, and then aqueous humor .The peak time of maximum drug concentration in rabbit's eye tissues and aqueous humor was two hours for various ophthalmic ointments and gels The total availability of enrofloxacin was improved when the drug was complexed with HP-β –CYD.